Microenvironmental regulation of therapeutic response in cancer
By F. Klemm, J. Joyce. Trends in Cell Biology, 2014
704 citations recorded by the source corpus.
The tumor microenvironment (TME) not only plays a pivotal role during cancer progression and metastasis but also has profound effects on therapeutic efficacy. In the case of microenvironment-mediated resistance this can involve an intrinsic response, including the co-option of pre-existing structural elements and signaling networks, or an adaptive response of the tumor stroma following the therapeutic insult. Alternatively, in other contexts, the TME has a multifaceted ability to enhance therapeutic efficacy. This review examines recent advances in our understanding of the contribution of the TME during cancer therapy and discusses key concepts that may be amenable to therapeutic intervention.
Subfields: Immunology, Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/faa48d3ee63a004b281082735397bc1892ab5fc5
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In Immunology
In Oncology
In Pathology and Forensic Medicine
Citations in the corpus
- Organoid modeling of the tumor immune microenvironment (2018, background): “The vast heterogeneity within cell types of the tumor microenvironment (TME) crucially impact treatment responses (Junttila and de Sauvage, 2013; Klemm and Joyce, 2015; Palucka and Coussens, 2016).”
- Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells (2020, background): “Although diverse TME cell types can critically regulate cancer progression and response to therapy across a broad range of extracranial tumors (Klemm and Joyce, 2015), we cannot simply extrapolate findings from these cancers to the singular brain TME, given its unique cell types, including astrocyte”
- Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Exosomal miRNA in Cancer The malignant phenotypes of tumors are not only determined by cancer cells themselves but also depend on the surrounding tumor microenvironments [25].”