Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

By Zhen Xie, Liliana Wroblewska, Laura Prochazka, Ron Weiss, Yaakov Benenson. Science, 2011

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Biomolecular computing systems: principles, progress and potential (2012, background): “Recently, a hybrid system was constructed that interrogates six endogenous miRNA markers to identify HeLa cancer cells 17 .”
Complex cellular logic computation using ribocomputing devices (2017, neutral): “9 and 10.”
Toehold Switches: De-Novo-Designed Regulators of Gene Expression (2014, background): “…(Friedland et al., 2009), oscillators (Elowitz and Leibler, 2000), toggle switches (Gardner et al., 2000), logic gates (Ausländer et al., 2012; Moon et al., 2012; Siuti et al., 2013; Win and Smolke, 2008), cell classifiers (Xie et al., 2011), and analog signal processors (Daniel et al., 2013).”
A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions (2012, methodology): “…regulators based on the sTFs described here can be used to create classiﬁer circuits to identify cell state (Nissim and Bar-Ziv, 2010; Xie et al., 2011), memory devices to record cellular events, and logic gates for cellular signal processing (Kramer et al., 2004), which can aid in…”
Attention-Based Transformers for Instance Segmentation of Cells in Microstructures (2020, background): “Ideally in synthetic biology, well characterised parts are combined in silico in a quantitatively predictive bottom up approach [11]–[13], for example, to detect and kill cancer cells [14], [15].”