Recent functional insights into the role of (p)ppGpp in bacterial physiology

By V. Hauryliuk, G. Atkinson, K. Murakami, T. Tenson, Kenn Gerdes. Nature Reviews Microbiology, 2015

756 citations recorded by the source corpus.

The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p)ppGpp metabolism and (p)ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp. We also discuss the structural basis of transcriptional regulation by (p)ppGpp and the role of (p)ppGpp in GTP metabolism and in the emergence of bacterial persisters.

Subfields: Genetics, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fa95a6ae6ee0d4eeaabe52bd52915fb07d6fea54

How researchers see this paper

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In Genetics

1. Kenn Gerdes
2. Etienne Maisonneuve
3. Alexander Harms

In Materials Chemistry

1. Kenn Gerdes
2. Etienne Maisonneuve

In Molecular Biology

1. Kenn Gerdes
2. Etienne Maisonneuve
3. Alexander Harms

Citations in the corpus

• Mechanisms of bacterial persistence during stress and antibiotic exposure (2016, background): “Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) collectively act in the “stringent response” as the ubiquitous second messenger and “alarmone” (p)ppGpp that is typically produced in response to nutrient starvation and other stresses to reprogram cellular physiology from growth”