Elements of cancer immunity and the cancer–immune set point

By Daniel S. Chen, I. Mellman. Nature, 2017

4,557 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/fa9134069165f345c416e781e798fc3fc22b6bba

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Citations in the corpus

Intratumoral Tcf1+PD‐1+CD8+ T Cells with Stem‐like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy (2019, neutral): “Naive tumor-specific T cells are thought to expand and differentiate in the tumor draining lymph node and differentiated T cells home to the tumor (Chen and Mellman, 2017).”
Mitochondrial metabolism and cancer (2017, background): “Thus, it is now widely accepted that tumors form, develop and respond to therapy in the context of a complex, bidirectional interaction with the host immune system [5, 6].”
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy (2019, background): “In general, tumors can be prognostically classified into phenotypes including “immune desert,” “immune excluded,” or “inflamed” based on their T cell infiltration (1).”
Neoantigens: promising targets for cancer therapy (2023, background): “Nevertheless, low TMB can produce neoantigen-reactive lymphocytes in hematological malignancies and certain epithelial cancers, such as gastrointestinal cancers.(10,240,478) The insufficient neoantigen density in malignancies with low TMB, such as AML and pediatric brain cancers, requires greater po”
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (2019, methodology): “Adopting general features of immune-based groupings described previously (Chen and Mellman, 2017) and incorporating transcriptomic and proteomic features, we defined four tumor subtypes in this ccRCC cohort: (1) CD8+ inflamed, (2) CD8− inflamed, (3) VEGF immune desert, and (4) metabolic immune deser”
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “Recently, it has been demonstrated that the efficacy of the treatment with immune checkpoint inhibitors can be influenced by the composition of the host gut microbiota (176).”
A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging (2018, neutral): “Cancer progression is a complex process that depends on the interplay between individual cells in the tumor, the microenvironment, and the immune system, which can act both to promote and suppress tumor growth and invasion (Chen and Mellman, 2017).”
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment (2018, background): “Approaches that target cells such as TAMs or factors including TGFβ, responsible for the formation of a mesenchymal stroma and for immunosuppression, are promising (2).”
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “The iTME is a dynamic system in which the combination of immune CT, location, and functional orientation leads to a tumorrejecting or tumor-promoting environment (Chen and Mellman, 2017; Fridman et al., 2017).”