Why rejection hurts: a common neural alarm system for physical and social pain.

By Naomi I. Eisenberger, Matthew D. Lieberman. Trends in Cognitive Sciences, 2004

1,196 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Physiology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/fa4966407bb904fd931d8f8fdbca024ebec0b389

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Citations in the corpus

Introduction to Interpersonal Acceptance-Rejection Theory (IPARTheory) and Evidence (2016, background): “…fact, brain imaging (fMRI) studies reveal that specific parts of the brain shown in Figure 5 tend to be activated when people feel rejected, just as they are when people experience physical pain (Eisenberger, 2012a, 2012b, 2015; Eisenberger & Lieberman, 2004; Eisenberger et al., 2003; Karos, 2018.”
A Socio-Ecological Approach to Cross-Cultural Differences in the Sensitivity to Social Rejection (2014, background): “This is due to the fact that social rejection brings individuals not only unpleasant experiences on both cognitive and physical levels (Eisenberger & Lieberman, 2004) but also can result in the concrete loss of emotional and material resources for living, which one could otherwise have received…”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “Combined with its role in error detection and conflict monitoring, the processing of social pain by the dACC has been suggested to comprise a neural “alarm system,” which can both detect and respond to threatening environmental stimuli (105).”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “…studied in the context of inflammation effects of neurocircuitry is the dorsal ACC (dACC, Brodmann’s Area 24), as it is a target of central cytokine action and has a critical role in detecting and responding to threatening social and physical pain stimuli (Eisenberger and Lieberman, 2004).”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “Increased activity in the dorsal ACC has been associated with high-trait anxiety, neuroticism, obsessive compulsive disorder and bipolar disorder (Eisenberger and Lieberman, 2004), all of which are associated with increased anxiety and arousal.”
Ostracism: The Kiss of Social Death (2007, positive): “These studies, and more under way, are providing evidence for two important conclusions: (i) the social pain of ostracism is linked closely to physical pain (see Eisenberger & Lieberman, 2004; MacDonald & Leary, 2005; Panksepp, 2003) and (ii) the initial painful response to ostracism is crude and ”
Meeting of minds: the medial frontal cortex and social cognition (2006, result): “This distinction is consistent with functional organizations suggested by Eisenberger and Lieberma”
Testing Predictions From Personality Neuroscience: Brain Structure and the Big Five (2010, methodology): “Agreeableness appears to identify the collection of traits related to altruism: one’s concern for the needs, desires, and rights of others (as opposed to one’s enjoyment of others, which appears to be related primarily to Extraversion).”
Broken Hearts and Broken Bones (2012, background): “Here, I review this emerging body of evidence, which has demonstrated that social pain relies on some of the same underlying neural circuitry that is associated with the unpleasant experience of physical pain (Eisenberger, 2011; Eisenberger & Lieberman, 2004).”
The role of lateral orbitofrontal cortex in the inhibitory control of emotion (2006, background): “This evaluation inhibits (or 'disrupts') negative affect through orbital-and ventral PFC-mediated 'top-down' neural projections that suppress neural activity associated with negative affect (Lieberman 2003; Eisenberger and Lieberman 2004).”