Remodelling the extracellular matrix in development and disease

By C. Bonnans, J. Chou, Zena Werb. Nature reviews. Molecular cell biology, 2014

3,853 citations recorded by the source corpus.

The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative changes in the ECM, mediated by specific enzymes that are responsible for ECM degradation, such as metalloproteinases. The ECM interacts with cells to regulate diverse functions, including proliferation, migration and differentiation. ECM remodelling is crucial for regulating the morphogenesis of the intestine and lungs, as well as of the mammary and submandibular glands. Dysregulation of ECM composition, structure, stiffness and abundance contributes to several pathological conditions, such as fibrosis and invasive cancer. A better understanding of how the ECM regulates organ structure and function and of how ECM remodelling affects disease progression will contribute to the development of new therapeutics.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/fa36bc3f120cb6b1febd52f4848123d1d4138916

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Citations in the corpus

The Extracellular Matrix: Tools and Insights for the “Omics” Era (2015, background): “IncreasedECMdegradation is a hallmark of pathologies such as osteoarthritis, fibrosis, and cancers [12].”
Extracellular matrix (ECM) stiffness and degradation as cancer drivers (2018, background): “Cleavage of ECM components is an important process for regulation of ECM composition, structure and abundance, as well as for release of biologically active molecules, such as growth factors.(20) In Figure 1, the functional features of ECM stiffness and degradation have been shown.”
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration (2020, background): “These processes are complex and need to be tightly regulated to maintain tissue homeostasis, especially in response to injury [89].”
Extracellular matrix structure. (2016, background): “The biological significance of MMPs in normal and pathological conditions like cancer is well characterized throughout the literature highlighting their pharmacological targeting [13, 170, 283-285].”
Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, background): “In 3D cells, difference in cell stage likely means that there are proliferating cells available in the outer region in the cell (Bonnans et al., 2014).”
Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “The hepatocyte growth factor (known as the scattering factor) is a multi-effect precursor protein and a mitogen of mature rat hepatocytes,(173) mainly derived from mesenchymal cells and activated by extracellular protease cleavage.(174) As a soluble heterodimer, HGF can be cleaved into α chain and β”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “Focal degradation of the basement membrane finally enables tumor cells to penetrate into the underlying interstitial stroma of the tissue (Bonnans et al., 2014; Guo and Giancotti, 2004) (Figure 3).”