Preventing and Managing Toxicities of High-Dose Methotrexate

By S. C. Howard, John McCormick, C. Pui, R. Buddington, R. Harvey. The Oncologist, 2016

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High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely administered to most patients, it can cause significant toxicity, including acute kidney injury. This article provides comprehensive recommendations for prevention of toxicity from HDMTX, along with detailed treatment guidance to mitigate acute kidney injury and subsequent toxicity.

Subfields: Nephrology, Pathology and Forensic Medicine, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/fa19ca69678b98be6be3eeeec1b87c9b982b99f0