Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

By R. Weller, M. Subash, S. D. Preston, I. Mazanti, R. Carare. Brain Pathology, 2008

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Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain (2013, background): “…contributes to paravascular CSF–ISF exchange suggests the possibility that age-related and cerebrovascular disease-related reductions in arterial pulsatility may additionally contribute to failure of the clearance of interstitial waste, including A , from the aged brain (Weller et al., 2008).”
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence (2017, background): “com 1249 AGING clearance mechanisms, leading to accumulation of toxic metabolites, neuronal death and progressive cognitive decline [11, 12].”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “Drainage of some brain interstitial fluid does occur in the perivascular spaces between blood vessel walls and brain parenchyma (Carare et al. 2008; Weller et al. 2008).”
Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, background): “Interestingly, seed placement in one region also can foster CAA in separate locations 51 , implicating perivascular fluid drainage channels 55 and/or vascular transport mechanisms in the dissemination of the seeds 51 .”