Neural Networks of the Mouse Neocortex

By Brian Zingg, Houri Hintiryan, Lin Gou, Monica Y. Song, Maxwell Bay, M. Bienkowski, Nicholas N. Foster, Seita Yamashita, Ian Bowman, Arthur W. Toga and 1 more. Cell, 2014

702 citations recorded by the source corpus.

SUMMARY Numerous studies have examined the neuronal inputs and/or outputs of many areas of the brain cortex, but how these areas organize into broader communication networks across the cortex is unclear. Over 600 labeled neuronal pathways acquired from tracer injections placed across the entire mouse neocortex enabled us to generate a cortical connectivity atlas. 240 intracortical connections were manually reconstructed within a common neuroanatomic framework, forming a cortico-cortical connectivity map that facilitates comparison of connections from different cortical targets. Connectivity matrices were generated to provide an overview of all intracortical connections and subnetwork clusterings. The connectivity matrices and cortical map revealed that the entire cortex is organized into four somatic sensorimotor, two medial, and two lateral subnetworks that display unique topologies and can interact through select cortical areas. Together, these data provide a resource that can be used to further investigate cortical networks and their corresponding functions.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/f9df953a64ee450ca0db637e367d1726cacf96ca

Citations in the corpus

• Advancing the understanding of autism disease mechanisms through genetics (2016, unknown): “Recent advances in connectomics 213,214 and optogenetics 215,216 may help in delineating the functional neural correlates for core ASD-associated behaviors, thus providing therapeutic opportunities. tory transmission by D1-dopamine receptor–expressing medium spiny neuron (D1-MSNs) in the nucleus…”
• Mapping of brain activity by automated volume analysis of immediate early genes (2016, unknown): “While the AI is not usually considered to be part of the “somatosensory Insula” (Rodgers et al., 2008), it is connected to the barrel cortex (Zingg et al., 2014).”