New strategies to improve minimap2 alignment accuracy

By Heng Li. Bioinform., 2021

1,040 citations recorded by the source corpus.

SUMMARY We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100kb by default, addressing major weakness in minimap2 v2.18 or earlier. AVAILABILITY AND IMPLEMENTATION https://github.com/lh3/minimap2.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f9c6307465f0b3b4d540b6e82ec5707e5812803b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Adam M. Phillippy
2. Evan E. Eichler
3. Benedict Paten
4. Paul Flicek
5. Mark J. P. Chaisson
6. Mitchell R. Vollger
7. Karen H. Miga
8. Jana Ebler

In Plant Science

1. Evan E. Eichler
2. David Haussler
3. Benedict Paten
4. Adam M. Phillippy
5. Mark J. P. Chaisson
6. Paul Flicek
7. Heng Li

Citations in the corpus

• A draft human pangenome reference (2022, methodology): “com/lh3/minimap2/tree/master/misc) (Li, 2021b), to count the number of apparent gene duplications for each of the assemblies produced by Hifiasm-v0.”