Annexins – unique membrane binding proteins with diverse functions
By U. Rescher, V. Gerke. Journal of Cell Science, 2004
597 citations recorded by the source corpus.
Annexins are a well-known multigene family of Ca2+-regulated phospholipid-binding and membrane-binding proteins. Recent work employing annexin-knockdown or - knockout models has provided new insights into the biological functions of different annexin proteins. Transient annexin depletion by RNA interference and the expression of dominant-negative mutant proteins has revealed roles for the proteins in membrane processes ranging from the control of membrane structure to certain membrane transport phenomena. Although such functions correlate well with the ability of annexins to interact with cellular membranes in a reversible and regulated manner, some activities are membrane independent, probably because annexins can also engage in specific protein-protein interactions. Among other things, this is evident in annexin A1- and A2-knockout mice, which show impaired regulation of neutrophil extravasation and defects in plasmin generation, respectively.
Subfields: Cancer Research, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/f96e4b94c5ab8f1cdd72bfb41761d840275dde3f
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In Molecular Biology
Citations in the corpus
- Annexins: linking Ca2+ signalling to membrane dynamics (2005, background): “Together with studies showing that annexin A2 can bind to membranes containing cholesterol in a Ca 2+ -independent manner (for a review, see Ref”
- Fibrinolysis and the control of blood coagulation. (2015, background): “Annexin A2, an important component of cell-based fibrinolysis, is a member of the annexin family of calcium-binding proteins that fulfill diverse physiologic functions [47–50].”