Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts.

By Tomotaka Okino, Yasutaka Hoashi, Y. Takemoto. Journal of the American Chemical Society, 2003

1,155 citations recorded by the source corpus.

Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).

Subfields: Organic Chemistry, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/f9634138c6b8c54e55761a6c41035d4cd6c3c4b8

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In Organic Chemistry

1. Philippe Schwaller

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1. Philippe Schwaller
2. Oliver Schilter
3. Andrew D. White
4. Sam Cox
5. Andrés M Bran
6. Carlo Baldassari

Citations in the corpus

• Augmenting large language models with chemistry tools (2023, methodology): “React (1R,2R)-(-)-2-isothiocyanato-4,4-dimethyl-3-oxasilinane with N-Boc-3,5-bis(trifluoromethyl)phenyl thiourea in the presence of a suitable base, such as triethylamine, in anhydrous DCM to yield the protected Takemoto’s organocatalyst.”