Clonal development and organization of the adult Drosophila central brain
By Hung-Hsiang Yu, T. Awasaki, Mark D. Schroeder, Fuhui Long, Jacob S. Yang, Yisheng He, Peng Ding, Jui-Chun Kao, Gloria Wu, Hanchuan Peng and 2 more. 2013
154 citations recorded by the source corpus.
Summary Background The insect brain can be divided into neuropils that are formed by neurites of both local and remote origin. The complexity of the interconnections obscures how these neuropils are established and interconnected through development. The Drosophila central brain develops from a fixed number of neuroblasts (NBs) that deposit neurons in regional clusters. Results By determining individual NB clones and pursuing their projections into specific neuropils we unravel the regional development of the brain neural network. Exhaustive clonal analysis revealed 95 stereotyped neuronal lineages with characteristic cell body locations and neurite trajectories. Most clones show complex projection patterns, but despite the complexity, neighboring clones often co-innervate the same local neuropil(s) and further target a restricted set of distant neuropils. Conclusions These observations argue for regional clonal development of both neuropils and neuropil connectivity throughout the Drosophila central brain.
Subfields: Cellular and Molecular Neuroscience, Immunology, Molecular Biology
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In Cellular and Molecular Neuroscience
- Yoshinori Aso
- Gerald M. Rubin
- Hiromu Tanimoto
- P. Plaçais
- T. Préat
- Nobuhiro Yamagata
- Toshiharu Ichinose
- M. Nitabach
In Immunology
In Molecular Biology
Citations in the corpus
- Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “One obvious possibility is neurons that project to the fan-shaped body of the central complex whose dendrites are known to widely arborize in these same areas (Hanesch et al., 1989; Young and Armstrong, 2010a; Ito et al., 2013; Yu et al., 2013).”
- The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “(A) The γd KCs are thought to be of embryonic origin, because they are not included in a clonal analysis that visualized all post-embryonic KCs (Lin et al., 2007; Yu et al., 2013), and they have morphological similarity to the embryonic born KCs of basal cockroaches (Farris and Strausfeld, 2003).”
- Systematic analysis of neural projections reveals clonal composition of the Drosophila brain. (2013, unknown): “in this issue of Current Biology [21], it is highly likely that the labeled neurons belong to a single neuroblast clone despite their distant locations.”