Modular regulatory principles of large non–coding RNAs

By M. Guttman, Johannes Rinn. Nature, 2012

2,186 citations recorded by the source corpus.

It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f8b15b2af1e484486a21b7b23c651833e3fe1397

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

NeST, a long noncoding RNA, controls microbial susceptibility and epigenetic activation of the Ifng locus (2013, neutral): “It is known that many lncRNAs are present at similarly low amounts but still are sufficient to cause epigenetic changes that are then selfpropagating (reviewed in Guttman and Rinn, 2012).”
Gene regulation by the act of long non-coding RNA transcription (2013, background): “Targeting of epigenetic modifiers (EMs) by lncRNAs provided a much sought after model to explain how EMs gain locus specificity (Figure 1d), and has since been suggested as a general mechanism for trans-acting lncRNAs [22,23].”
Linking Long Noncoding RNA Localization and Function. (2016, background): “The same patterns are also associated with protein-coding genes [3,4,49,50].”
Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “LncRNAs regulate the target gene expression, mainly through cis-regulation or trans-regulation [12].”