Mobile Genetic Elements Associated with Antimicrobial Resistance
By S. Partridge, S. Kwong, N. Firth, S. Jensen. Clinical Microbiology Reviews, 2018
2,104 citations recorded by the source corpus.
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world. It is now abundantly clear that both Gram-negative and Gram-positive bacteria are able to meet the evolutionary challenge of combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from the bacterial gene pool. SUMMARY Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world. It is now abundantly clear that both Gram-negative and Gram-positive bacteria are able to meet the evolutionary challenge of combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from the bacterial gene pool. This is achieved through the concerted activities of mobile genetic elements able to move within or between DNA molecules, which include insertion sequences, transposons, and gene cassettes/integrons, and those that are able to transfer between bacterial cells, such as plasmids and integrative conjugative elements. Together these elements play a central role in facilitating horizontal genetic exchange and therefore promote the acquisition and spread of resistance genes. This review aims to outline the characteristics of the major types of mobile genetic elements involved in acquisition and spread of antibiotic resistance in both Gram-negative and Gram-positive bacteria, focusing on the so-called ESKAPEE group of organisms (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., and Escherichia coli), which have become the most problematic hospital pathogens.
Subfields: Infectious Diseases, Molecular Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/f8929a419569db7091b4ecb074f2da57ab402c7d
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In Infectious Diseases
In Molecular Biology
In Molecular Medicine
Citations in the corpus
- mobileOG-db: a Manually Curated Database of Protein Families Mediating the Life Cycle of Bacterial Mobile Genetic Elements (2021, background): “The rapidly increasing volume of sequence data has outpaced the ability to annotate and classify MGEs, in part due to a lack of a suitable knowledgebase (39).”
- Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “The association of AMR and MGEs has been extensively reviewed recently (262).”