Childhood adversities and adult psychopathology in the National Comorbidity Survey Replication (NCS-R) II: Associations with persistence of DSM-IV disorders
By Katie A. McLaughlin, J. Green, M. Gruber, N. Sampson, Alan M. Zaslavsky, Ronald C. Kessler. Archives of General Psychiatry, 2010
652 citations recorded by the source corpus.
Context Although significant associations of childhood adversities (CAs) with adult mental disorders have been widely documented, associations of CAs with onset and persistence of disorders have not been distinguished. This distinction is of considerable importance for both conceptual and practical purposes. Objective To examine the multivariate associations of 12 retrospectively reported CAs with persistence of adult DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Design Cross-sectional community survey Setting/Participants Nationally representative sample of 5,692 adults in the US household population. Intervention None Main Outcome Measures Recency of episodes was assessed separately for each of 20 lifetime DSM-IV mood, anxiety, disruptive behavior, and substance disorders among respondents with a lifetime history of these disorders using the WHO Composite International Diagnostic Interview (CIDI). Predictors of persistence were examined using backward recurrence survival models to predict time-since-most-recent-episode controlling for age-of-onset and time-since-onset. Results CAs involving maladaptive family functioning (MFF) (parental mental illness, substance disorder, criminal behavior, family violence, abuse, neglect) but not other CAs were significantly but modestly related to persistence of mood, substance, and anxiety disorders. Number of MFF CAs had statistically significant, but again substantively modest, sub-additive associations with the same outcomes. Exposure to multiple other CAs was significantly associated with persistence of mood and anxiety disorders. Associations remained statistically significant throughout the life course, although the substantive size of associations indicated by simulations showing time to most recent episode would increase by only 1.6% (from a mean of 8.3 years to a mean of 8.4 years) in the absence of CAs. Conclusions The overall statistically significant associations of CAs with adult DSM-IV/CIDI disorders are due largely to component associations with onsets rather than persistence, indirectly suggesting that the greatest focus of public health attention on CAs should be aimed at primary prevention rather than secondary prevention.
Subfields: Clinical Psychology
View Paper: https://www.semanticscholar.org/paper/f8840de8b560aa24cde57cc2a7308e832e6209b3
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In Clinical Psychology
Citations in the corpus
- The Role of Early Life Stress in Adult Psychiatric Disorders: A Systematic Review According to Childhood Trauma Subtypes (2013, background): “…Green et al., 2010; Hovens et al., 2010; Jonas et al., 2011; Katerndahl et al., 2005; Kessler et al., 2010; Khoury et al., 2010; Lang et al., 2004; McLaughlin et al., 2010a, 2010b; Molnar et al., 2001a, 2001b; Sareen et al., 2005; Wingenfeld et al., 2011; Wonderlich et al., 2007) and particularly…”
- The Role of Early Life Stress as a Predictor for Alcohol and Drug Dependence (2010, background): “A community survey, the NCS-R, showed that retrospectively reported childhood stressors (SLE plus maltreatment) predicted 26% of substance use disorders with onset at ages 13– 29 years (Green et al. 2010) but did not predict persistence of the disorders (McLaughlin et al. 2010).”
- Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review (2014, neutral): “Nine untranslated first exon variants each possessing their own promoter region have been identified in humans (1A, I, D, J, E, B, F, C and H) and in rats (11, 4-11).”