Neutrophil migration in infection and wound repair: going forward in reverse

By S. de Oliveira, E. Rosowski, A. Huttenlocher. Nature reviews. Immunology, 2016

939 citations recorded by the source corpus.

Neutrophil migration and its role during inflammation has been the focus of increased interest in the past decade. Advances in live imaging and the use of new model systems have helped to uncover the behaviour of neutrophils in injured and infected tissues. Although neutrophils were considered to be short-lived effector cells that undergo apoptosis in damaged tissues, recent evidence suggests that neutrophil behaviour is more complex and, in some settings, neutrophils might leave sites of tissue injury and migrate back into the vasculature. The role of reverse migration and its contribution to resolution of inflammation remains unclear. In this Review, we discuss the different cues within tissues that mediate neutrophil forward and reverse migration in response to injury or infection and the implications of these mechanisms to human disease.

Subfields: Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/f84b5bd6c1ba3063974f0009babc4e4935bfbc6a

Citations in the corpus

• Cellular and molecular mechanisms of skin wound healing (2024, neutral): “…down the rolling neutro phils so they can spread and crawl along the luminal surface of vessels until they can migrate across the endothelial and pericyte layers, exit from the blood vessels into the surrounding area (diapedesis), and begin their interstitial migration towards the wound 81,82 (Fig.”