The Validity and Precision of the Comparative Interrupted Time-Series Design

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The use of controls in interrupted time series studies of public health interventions. (2018, methodology): “Controlled interrupted time series A controlled (or comparative) interrupted time series (CITS) involves adding a control series, which was not exposed to the intervention, to the basic ITS design (Figure 1).(9) This results in the definition of a more complex counterfactual based on both a before-a”