Prognostic Relevance of CD4+, CD8+ and FOXP3+ TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers

By P. Lequerica-Fernández, Julián Suárez-Canto, T. Rodríguez-Santamarta, J. Rodrigo, F. J. Suárez-Sánchez, V. Blanco-Lorenzo, Francisco dominguez-iglesias, J. García-Pedrero, J. D. de Vicente. 2021

Subfields: Immunology, Oncology, Oral Surgery

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1. M. Knebel
2. Maximilian Linxweiler
3. S. Körner
4. L. Brust
5. S. Wemmert
6. J. Kühn
7. R. Bohle
8. B. Schick

Citations in the corpus

• Prognostic impact of intra- and peritumoral immune cell subpopulations in head and neck squamous cell carcinomas – comprehensive analysis of the TCGA-HNSC cohort and immunohistochemical validation on 101 patients (2023, background): “the interaction of cytotoxic T cells with FoxP3+ regulatory T cells as represented by the CD8/FoxP3 ratio (43), one can even enhance the robustness and validity of CD8+ T cells as biomarker for beneficial clinical outcome in head and neck cancer (43, 45, 46).”