Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

By W. Ageno, A. Gallus, A. Wittkowsky, M. Crowther, E. Hylek, G. Palareti. Chest, 2012

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Efficacy and Safety of a 4-Factor Prothrombin Complex Concentrate in Patients on Vitamin K Antagonists Presenting With Major Bleeding A Randomized, Plasma-Controlled, Phase IIIb Study (2013, background): “Fluid overload and similar cardiac events occurred relatively frequently after plasma transfusion for VKA reversal, as previously described.(7,29) PCCs have several safety advantages compared with plasma with respect to rare but important AEs, many of which are not measurable in a trial such as this”