NMR-Based Screening of Proteins Containing 13C-Labeled Methyl Groups

By Philip J. Hajduk, D. Augeri, J. Mack, Renaldo Mendoza, Jianguo Yang, A. Betz, Stephen W. Fesik. 2000

192 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f746d488a95e56276ca448e6c5c11008269a8ccb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. M. Williamson
2. Roderick E. Hubbard

In Molecular Biology

1. M. Williamson
2. Stephen W. Fesik
3. Roderick E. Hubbard

Citations in the corpus

• Twenty years on: the impact of fragments on drug discovery (2016, background): “The size of the fragment library can vary widely from 500 to 20,000 molecules 7,25 .”
• Using chemical shift perturbation to characterise ligand binding. (2013, background): “Because there are three protons in the methyl group and the signals are slowly relaxing and consequently sharp, these signals tend to be of high intensity: an early study [38] showed that protein concentrations as low as 15 lM give useful spectra.”