Landscape of Somatic Retrotransposition in Human Cancers

By E. Lee, Rebecca C. Iskow, Lixing Yang, O. Gokcumen, Psalm S. Haseley, Lovelace J. Luquette, Jens G. Lohr, C. Harris, Li Ding, Richard K. Wilson and 6 more. Science, 2012

726 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f73b814de254adf4a6b731b5af4d1991c4b7b690

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Steve Rozen
2. J. Tyler
3. Michael Olivier
4. Ioana Cutcutache
5. Sangita Pal
6. L. Cox
7. Reedik Mägi
8. Eric P. Xing

In Plant Science

1. Michael Olivier
2. Reedik Mägi
3. Eric P. Xing
4. Seyoung Kim
5. Daniela M. Witten
6. Robert Tibshirani

Citations in the corpus

• The Need for Multi-Omics Biomarker Signatures in Precision Medicine (2019, background): “and profile the genome of 33 different tumor types and 10 rare cancers, sequenced the genomes of over 7500 samples to identify sequence variants [30], other DNA alterations such as fusions [31,32], copy number alterations [33,34], and other complex structural variations [35].”
• Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma (2017, background): “Recent studies have shown that certain L1 elements are active in cancer, displaying somatic retrotransposition and potentially contributing to genomic instability and tumorigenesis (28-30).”
• Epigenetics and aging (2016, background): “Given the many recent links between activation of retrotransposable elements and aging, it is interesting to note that transposition also becomes more frequent during cancer development (74, 75), wherein aging is the highest risk factor for most cancers.”