In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise
By N. Ho, J. Hooker, Amar Sahay, D. Holt, J. Roffman. 2013
97 citations recorded by the source corpus.
New neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we are able to detect and measure levels of adult neurogenesis in living human brains—a formidable challenge for now—we cannot establish its functional importance in human health, disease and new treatment development. Current non-invasive neuroimaging modalities can provide live snapshots of the brain’s structure, chemistry, activity and connectivity. This review explores whether existing macroscopic imaging methods can be used to understand the microscopic dynamics of adult hippocampal neurogenesis in living individuals. We discuss recent studies that have found correlations between neuroimaging measures of human hippocampal biology and levels of pro- or anti-neurogenic stimuli, weigh whether these correlations reflect changes in adult neurogenesis, detail the conceptual and technical limitations of these studies and elaborate on what will be needed to validate in vivo neuroimaging measures of adult neurogenesis for future investigations.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Radiology, Nuclear Medicine and Imaging
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Developmental Neuroscience
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “Efforts to evaluate AHN in vivo face limitations due to inadequate spatial resolution and the inability to accurately differentiate hippocampal sub-regions (Ho et al., 2013; Manganas et al., 2007; Ramm et al., 2009).”
- Age Differences in Hippocampal Subfield Volumes from Childhood to Late Adulthood (2015, background): “Neurogenesis, however, is restricted to the DG and, even in that structure, its extent in humans is largely unknown and its role in hippocampal volume maintenance has never been tested (Ho et al., 2013; Breunig et al., 2007).”