Tumor Regression by Targeted Gene Delivery to the Neovasculature

By J. Hood, M. Bednarski, R. Frausto, S. Guccione, R. Reisfeld, R. Xiang, D. Cheresh. Science, 2002

867 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f6cb2fcc7565e19b21e3b3c79941be3bcf491464

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In Immunology and Allergy

K. Krishnan

In Molecular Biology

Citations in the corpus

Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival (2008, neutral): “(130, 131) and in T cell differentiation (110, 132, 133).”
BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis (2004, background): “Recent evidence suggests that Raf-1 and BRAF participate in the regulation of endothelial apoptosis and, therefore, angiogenesis, a process essential for tumor development and metastasis (15, 16).”
Nanoparticle and targeted systems for cancer therapy. (2004, background): “Recent work has also shown that gene delivery may also be targeted to neovasculature by coupling lipid-based cationic nanoparticles to an integrin avh-targeting ligand in tumor-bearing mice [23].”
An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “Develop angiogenesis (Eliceiri et al., 1998; Giroux et al., 1999; Hood et al., 2002), and has been advanced as an antiangiogenic therapy (Hood et al.”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “Cyclic or linear derivatives of the Arg-Gly-Asp (RGD) oligopeptide have been studied extensively to bind to endothelial avb3 integrin, which may be exploited for tumoral endothelium targeting (Hood et al., 2002; Desgrosellier and Cheresh, 2010).”
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy (2010, positive): “Nanoparticle encapsulated liposomes, coated with an appropriate -binding ligand, such as Tetrac [151] or RGD peptides [152], to target the neovasculature and embedded with a mutant form of the gene has been shown to disrupt the normal activity of the Raf-1 gene by blocking endothelial signaling and ”