COVID-19 pandemic, coronaviruses, and diabetes mellitus

By R. Muniyappa, Sriram Gubbi. American Journal of Physiology. Endocrinology and Metabolism, 2020

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The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/f6badaf011855df2b35f7e4b08f89c2d523a21e3