The protein folding 'speed limit'.

By J. Kubelka, J. Hofrichter, W. Eaton. Current Opinion in Structural Biology, 2004

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Molecular chaperones in protein folding and proteostasis (2011, background): “Why is this extra layer of complexity necessary? Although small proteins may fold at very fast speed”
Protein folding studied by single-molecule FRET. (2008, background): “In this regime, the free energy barrier to folding is assumed to be extremely low or even absent, and diffusive chain dynamics become the dominant factor in folding kinetics [ 45 ].”
Biomolecules under mechanical force (2010, background): “Typical time scales for protein folding are 10−6 to 101 s [130].”
The protein folding problem. (2008, background): “More than a dozen proteins fold in microseconds (128).”