Targeting apoptosis pathways in cancer therapy.

By Simone Fulda, K. Debatin. Current Cancer Drug Targets, 2004

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “Current cancer therapies, for example, chemotherapy, g-irradiation, immunotherapy or suicide gene therapy, primarily exert their antitumor effect by triggering apoptosis in cancer cells (Makin and Dive, 2001; Fulda and Debatin, 2004).”
Apoptosis in cancer: from pathogenesis to treatment (2011, background): “Caspase 3 then cleaves the inhibitor of the caspase-activated deoxyribonuclease, which is responsible for nuclear apoptosis [30].”
Cancer despite immunosurveillance: immunoselection and immunosubversion (2006, background): “As an example, numerous DNA-damaging agents induce the expression of death receptors such as TRAIL receptor 1 (TRAILR1), TRAILR2 and CD95 by tumour cells, thereby facilitating the lysis of these cells by TRAIL- or CD95L-expressing immune effector cell”
Cellular Stress Responses: Cell Survival and Cell Death (2010, neutral): “[291] S.”