HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity

By Steven G. Deeks, A. Phillips. British medical journal, 2009

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Causes of Death in HIV-1–Infected Patients Treated with Antiretroviral Therapy, 1996–2006: Collaborative Analysis of 13 HIV Cohort Studies (2010, neutral): “ventionally considered to be HIV-1 related [3].”
Premature age-related comorbidities among HIV-infected persons compared with the general population. (2011, background): “It has been hypothesized that the increased prevalence of NICM observed amongHIV-infected patients [2, 18], compared with the general population, is the result of premature aging in the former [11, 19].”
Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study (2015, background): “Aging [6], high-risk behaviour [7], co-infections [8], ART toxicity [9], CD4+ T cell depletion [10, 11], microbial translocation [12] and immune activation [13–19] all appear to contribute to SNAE pathogenesis.”