Alu repeats and human genomic diversity
By Mark A. Batzer, P. Deininger. Nature reviews genetics, 2002
1,491 citations recorded by the source corpus.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/f5c7d2b169fb668bc927c9ceccea558a83748aa0
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In Molecular Biology
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Citations in the corpus
- LINE-mediated retrotransposition of marked Alu sequences (2003, background): “In humans, the most prominent SINE family comprises the Alu element”
- The Diploid Genome Sequence of an Individual Human (2007, background): “Most of these SINE insertions (88%) belong to the youngest Alu family (AluY), for which insertion polymorphisms are well documented in the human genome [52,53].”
- Repetitive Elements May Comprise Over Two-Thirds of the Human Genome (2011, background): “Understanding the content and origins of this huge uncharacterized component of the genome represents an important step towards completely deciphering the organization and function of the human genome sequence [4,5,6].”
- LINE-1 Elements in Structural Variation and Disease (2011, background): “Alu elements arose in mammalian genomes ~65 Mya and contain two monomeric sequences derived from the signal recognition particle (SRP) 7SL RNA (14, 238).”
- Repetitive DNA and next-generation sequencing: computational challenges and solutions (2011, background): “Most large genomes are filled with repetitive sequences; for example, nearly half of the human genome is covered by repeats, many of which have been known about for decade”
- The impact of retrotransposons on human genome evolution (2009, neutral): “as a result of their continued mobilization activity over the past ∼65 My”
- DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007, background): “, there are >106 Alu repeats in the human genome [71], and more than 10% of the human genome is comprised of repeat sequences [72].”
- Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome (2004, background): “Alu elements are short interspersed elements found in all primates, which are approximately 300 nt in length (Batzer and Deininger 2002).”
- Adaptive seeds tame genomic sequence comparison. (2011, methodology): “Figure 3A presents results for the alignment of Homo sapiens promoters to the Mus musculus genome using contiguous seeds (black) or a previously identified optimal spaced seed pattern (Ma et al. 2002), 111010010100110 (red).”
- Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing (2008, background): “Moreover, there is no known mechanism for the specific removal of an Alu element from the germlin”