Upstream Open Reading Frames as Regulators of mRNA Translation

By D. Morris, A. Geballe. Molecular and Cellular Biology, 2000

764 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f567ff89888a4f265b8ad476032688633ba92c2a

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Citations in the corpus

Pushing the limits of the scanning mechanism for initiation of translation (2002, neutral): “The amino acid sequence of the inhibitory peptide is different in each case (Morris and Geballe, 2000) .”
Patterns, mechanisms, and functions of translation regulation in mammalian spermatogenic cells (2004, background): “…of sequences alone, because they are determined 220 Cytogenet Genome Res 103:217–224 (2003) by a complex mixture of factors such as the length, number and spacing of the uORFs, the amino acid sequence of the uORFs, and the context of the initiation codon of the uORF (Morris and Geballe, 2000).”
Internal ribosome entry sites in eukaryotic mRNA molecules. (2001, background): “It is possible for ribosomes to reinitiate after translation of an upstream open reading frame (Morris and Geballe 2000).”
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans (2009, background): “Because eukaryotic ribosomes usually load on the 5 cap of mRNA transcripts and scan for the presence of the first AUG start codon, uORFs can disrupt the efficient translation of the downstream coding sequence (1, 2).”
The integrated stress response: From mechanism to disease (2020, background): “Although it is assumed that they reinitiate at downstream codons, nascent peptides that emerge upon translation of uORFs could cause ribosome stalling (59).”
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity of Mammalian Proteomes (2011, background): “The first uORF in the Atf4 transcript is constitutively translated, and ribosomes then reinitiate at either the second uORF or the CDS (Calvo et al., 2009; Lu et al., 2004; Morris and Geballe, 2000) (Figure 6B).”
Deep learning of the regulatory grammar of yeast 5′ untranslated regions from 500,000 random sequences (2017, neutral): “…before the primary ORF start codon, or an out-of-frame up-stream AUG (uAUG) followed by a stop codon before or after the primary ORF start codon (Morris and Geballe 2000; Wang and Rothnagel 2004; Dvir et al. 2013). uORFs compete with the primary ORF, often producing nonsensical polypeptides and…”
Coronavirus Genome Structure and Replication (2005, background): “Certainly, short upstream ORFs can have profound enhancing or suppressing effects on the translation of a downstream ORF (Morris and Geballe 2000) , and their universal existence in coronavirus 5 0 UTRs, albeit with little or no conservation in size or amino acid sequence (Table 1) , would suggest t”