Biosensing with Luminescent Semiconductor Quantum Dots

By Kim E. Sapsford, T. Pons, Igor L. Medintz, H. Mattoussi. Italian National Conference on Sensors, 2006

392 citations recorded by the source corpus.

Luminescent semiconductor nanocrystals or quantum dots (QDs) are a recently developed class of nanomaterial whose unique photophysical properties are helping to create a new generation of robust fluorescent biosensors. QD properties of interest for biosensing include high quantum yields, broad absorption spectra coupled to narrow size-tunable photoluminescent emissions and exceptional resistance to both photobleaching and chemical degradation. In this review, we examine the progress in adapting QDs for several predominantly in vitro biosensing applications including use in immunoassays, as generalized probes, in nucleic acid detection and fluorescence resonance energy transfer (FRET) - based sensing. We also describe several important considerations when working with QDs mainly centered on the choice of material(s) and appropriate strategies for attaching biomolecules to the QDs.

Subfields: Biomedical Engineering, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f5090a2611f368923103970dc3ac8d11ecafb19a

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In Biomedical Engineering

1. J. Novak
2. Maureen A. Walling
3. J. R. Shepard

In Materials Chemistry

1. J. Novak
2. Maureen A. Walling
3. J. R. Shepard

In Molecular Biology

1. J. Novak
2. Maureen A. Walling
3. J. R. Shepard

Citations in the corpus

• Quantum Dots for Live Cell and In Vivo Imaging (2009, background): “While detailed discussions regarding FRET are beyond the scope of this review, many other good reviews exist on the topic [97-100].”