Alternative cleavage and polyadenylation: extent, regulation and function

By Ran Elkon, Alejandro P Ugalde, Reuven Agami. Nature reviews genetics, 2013

762 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f50426a7e05ffb234ac37fe732016255481274d7

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In Molecular Biology

1. Carlos Martínez-A
2. Carmen Mora Gallardo
3. K. V. van Wely
4. Ainhoa Sánchez de Diego

Citations in the corpus

• RNA-Binding Proteins in Cancer: Old Players and New Actors. (2017, background): “This involves endonucleolytic cleavage of the transcript followed by the addition of a long stretch of adenosines which is required for nuclear export, stability of mature transcripts, and efficient translation of mRNAs [86][162_TD$DIFF].”
• Interplay between splicing and transcriptional pausing exerts genome-wide control over alternative polyadenylation (2021, background): “This phenomenon, termed alternative polyadenylation (APA) is an important regulator of mRNA isoform expression [4].”