HPV-positive status associated with inflamed immune microenvironment and improved response to anti-PD-1 therapy in head and neck squamous cell carcinoma

By Jian Wang, hao-Ting sun, Q. Zeng, Xue-Jun Guo, Hui Wang, Huan Liu, Z. Dong. 2019

Subfields: Immunology and Allergy, Oncology, Otorhinolaryngology

Citations in the corpus

• Heterogeneity of PD-L1 Expression Between the Primary Tumor and Matched Lymph Node Metastases in Head and Neck Squamous Cell Carcinomas (2026, unknown): “Yang et al. and Chu et al. demonstrated a strong correlation between HPV positivity and increased tumoral PD-L1 expression [31,35], whereas Wang et al. found no significant correlation between PD-L1 expression and HPV tumor status, analyzing the TCGA-HNSC cohort [36].”
• Impact of T Cell Exhaustion and Stroma Senescence on Tumor Cell Biology and Clinical Outcome of Head and Neck Squamous Cell Carcinomas (2024, unknown): “Exemplarily, Wang et al. demonstrated that the HPV status can predict the efficacy of PD-1 inhibition in HNSCC patients independent of PD-L1 expression, likely due to an HPV-induced inflamed immune microenvironment [37].”