A Perspective on Cancer Cell Metastasis

By Christine L. Chaffer, R. Weinberg. Science, 2011

4,612 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/1d2323f8127772604b6d0a33f43cc50d7599c307

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. R. Huang
2. Tetsuo Noda
3. M. Nieto
4. J. P. Thiery
5. Yoshio Miki
6. T. Tan
7. Xiaohua Li
8. S. Mori

In Cancer Research

1. Lisa M. Coussens
2. D. Hanahan
3. R. Huang
4. Tetsuo Noda
5. M. Nieto
6. J. P. Thiery
7. Yoshio Miki
8. T. Tan

In Oncology

1. J. P. Thiery
2. M. Nieto
3. R. Huang
4. Lisa M. Coussens
5. D. Hanahan
6. Tetsuo Noda
7. Yoshio Miki
8. T. Tan

Citations in the corpus

• Autophagy and autophagy-related proteins in cancer (2020, background): “Once the metastatic cancer cells successfully establish distant colonies in their destination organs, autophagy begins to play a critical role and the autophagic flux is induced to respond various environmental stress including hypoxia, nutrient deprivation and detachment from the ECM [187, 240, 247”
• Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “T regs are also recruited into neoplastic tissues by other cytokines, most notably CCL2 and TGF-b; their abundance (and hence their indictment as tumor promoting) correlates with poor outcome for several cancer types (van der Vliet et al., 2007).”
• Investigating the optimal size of anticancer nanomedicine (2014, background): “Metastatic cancer is regarded as an incurable disease by conventional methods, including surgical resection, chemotherapy, and radiation therapy, and responsible for over 90% of cancerrelated death (37).”
• EMT and tumor metastasis (2015, background): “Onder T, Gupta P, Mani S, Yang J, Lander E, Weinberg R. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.”
• Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications (2016, background): “Approximately 90 % of cancer mortalities occur in patients with tumors derived from epithelial tissues, and the primary cause of death in such cases results from dissemination of tumor cells to distant organs [139].”
• Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells (2013, background): “ing Snail, Twist, Zeb, and others (4), which are generally termed EMT-TFs (5).”
• Targeting cancer stem cell pathways for cancer therapy (2020, background): “26 Since stromal cells (such as granulocytes and macrophages) secrete signaling molecules in the tumor microenvironment (TME), these cells stimulate epithelial-mesenchymal transformation (EMT) to promote the invasion of tumor cells, 27 which induce differentiated human mammary epithelial cells to fo”