Measuring and manipulating brain connectivity with resting state functional connectivity magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS)

By Michael D. Fox, Mark A. Halko, Mark C. Eldaief, Alvaro Pascual-Leone. NeuroImage, 2012

392 citations recorded by the source corpus.

Both resting state functional magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS) are increasingly popular techniques that can be used to non-invasively measure brain connectivity in human subjects. TMS shows additional promise as a method to manipulate brain connectivity. In this review we discuss how these two complimentary tools can be combined to optimally study brain connectivity and manipulate distributed brain networks. Important clinical applications include using resting state fcMRI to guide target selection for TMS and using TMS to modulate pathological network interactions identified with resting state fcMRI. The combination of TMS and resting state fcMRI has the potential to accelerate the translation of both techniques into the clinical realm and promises a new approach to the diagnosis and treatment of neurological and psychiatric diseases that demonstrate network pathology.

Subfields: Cognitive Neuroscience, Neurology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/f4067f81983235afb2466bccf495f40e4056092b

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Citations in the corpus

Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity (2012, positive): “Given the anticorrelation between limbic regions and the DLPFC even in normal subjects, DLPFC hypometabolism could be secondary to limbic hyperactivity rather than causal in the disease process (Fox et al., 2012a).”
Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines (2020, positive): “The combination of TMS with brain imaging has become common, if not standard, in research settings (Fox et al., 2012; Siebner et al., 2009) including large-scale clinical trials of rTMS for depression (Blumberger et al.”
Optimization of multifocal transcranial current stimulation for weighted cortical pattern targeting from realistic modeling of electric fields (2013, positive): “As an especially interesting example, we discuss the use of rs-fcMRI seed maps (Fox et al., 2012b; Shafi et al., 2012) for defining cortically extended tCS targets.”
Quantifying and reporting the precision of transcranial magnetic stimulation targeting. (2024, unknown): “…2019; Hermiller, 2020; Freed-berg, 2020; Hermiller, 2022), amygdala (Oathes, 2021; Sydnor, 2022), as well as to perform cross-network connectivity analyses (Fox, 2012; Fox et al., 2013; Cash, 2021; Cash, 2019; Weigand, 2018) to identify cortical stimulation targets in networks of interest.”