Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.

By D. Geller, Anita Farhi, Nikki Pinkerton, Michael Fradley, M. Moritz, A. Spitzer, G. Meinke, F. Tsai, P. Sigler, R. Lifton. Science, 2000

626 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/f3dd228e5c9a9f9393751836765cc8f70aa64a0f

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In Endocrinology, Diabetes and Metabolism

1. G. MacGregor
2. F. He

Citations in the corpus

• Molecular Mechanisms of Human Hypertension (2001, positive): “Indeed, all pregnancies among patients harboring this mutation have been complicated by dramatic acceleration of hypertension associated with complete suppression of the renin-angiotensin system (Geller et al., 2000).”
• Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. (2005, background): “This was in particular the case for spironolactone, which is converted into a rather potent agonist, and for progesterone, thus accounting for the remarkably severe presentation of the phenotype during pregnancy (113).”