Quorum-sensing inhibitors as anti-pathogenic drugs.

By T. B. Rasmussen, M. Givskov. International Journal of Medical Microbiology, 2006

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The threat of antimicrobial resistance in developing countries: causes and control strategies (2017, background): “Prior vaccination may reduce severity of disease, provide protection against shedding of pathogens and even raise the threshold load of pathogens required for infection [51-53].”
Microbial biosurfactants production, applications and future potential (2010, background): “However, recent studies have suggested that non-antibiotic molecules naturally produced within bacterial communities, including secreted signalling molecules or surface-active biosurfactants, could also interfere with biofilm formation, modulating microbial interaction with interfaces (Neu 1996; Fed”
Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control. (2015, background): “Three main pharmacological targets of QS systems include the signal generator, the QS molecule itself and the signal receptor (Rasmussen & Givskov, 2006).”
Indole as an intercellular signal in microbial communities. (2010, background): “Hence, 7-hydroxyindole (Lee et al., 2009a) could potentially be used for antivirulence therapies (Lesic et al., 2007; Cegelski et al., 2008), which are also known as antipathogenic drugs (Rasmussen & Givskov, 2006).”