A smartphone-based quantitative point-of-care testing (POCT) system for simultaneous detection of multiple heavy metal ions

By Zhenlin Xu, Zijian Liu, Meng Xiao, Lelun Jiang, C. Yi. 2020

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Abstract It is of great significance to develop versatile and cost-effective point-of-care testing (POCT) systems for simultaneous quantitation of multiple analytes on-site. This work reports on: 1) the customized electrodes which exhibit good analytical performance for simultaneous detection of Cd2+, Cu2+, Hg2+, Pb2+ with low detection limits (Cd2+, 0.296 μM; Cu2+, 0.055 μM; Hg2+, 0.351 μM; and Pb2+, 0.025 μM) and wide dynamic ranges (Cd2+, 0.50–12.5 μM; Cu2+, 0.10–9.50 μM; Hg2+, 0.50–12.5 μM; and Pb2+, 0.10–12.5 μM) using differential pulse voltammetry (DPV) measurements. 2) a hand-held electrochemical analyzer which can realize two-way communication with a smartphone and implement DPV measurements; its cost, weight and power consumption are ~$10.0, ~30 g and ~ 253 mW, respectively; 3) a self-developed APP DHMI which can control the analyzer, receive data from the analyzer, and plot the voltammograms on smartphone’s screen in real-time. This quantitative POCT system has been successfully demonstrated for simultaneous quantitation of Cd2+, Cu2+, Hg2+, Pb2+ in tap water, mineral water and Pearl River water, and the quantitation results correlated well with ICP-MS measurements. The features of cost-effectiveness, ease-to-use and reliability make this quantitative POCT system useful for on-site monitoring of multiple heavy metal ions, especially in resource-constrained environments.

Subfields: Biomedical Engineering, Electrochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f344195c57ee39af85570470a06e3093a94e3410