IL-6/IL-6 receptor system and its role in physiological and pathological conditions.

By M. Mihara, M. Hashizume, H. Yoshida, Miho Suzuki, M. Shiina. Clinical science, 2012

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Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “It is also known to stimulate osteoclast formation, induce bone resorption and is responsible for neural differentiation [24].”
CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. (2015, background): “It is produced by many different cell types, including monocytes/macrophages, dendritic cells, T cells, fibroblasts, keratinocytes, endothelial cells, myocytes, adipocytes, mesangial cells, and osteoblasts.(66) Our group was the first to target IL-6 signaling in patients who developed severe CRS aft”
The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease (2020, background): “The biology of IL-6 is complex with cytokine engagement of membrane anchored IL-6R and gp130 co-receptor being known to have tissue homeostatic and repair responses [44] .”
Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies (2014, background): “Conversely, IL-6 is an inflammatory cytokine involved in a large number of processes, both within the immune system, such as neutrophil trafficking, acute phase response, angiogenesis, B cell differentiation, and autoantibody production, and outside it, such as bone and lipid metabolism.(24) IL-6 is”