H pylori antibiotic resistance: prevalence, importance, and advances in testing

By F. Mégraud. Gut, 2004

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How researchers see this paper

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Helicobacter pylori Detection and Antimicrobial Susceptibility Testing (2007, background): “recently published systematic review (357).”
Helicobacter pylori treatment in the era of increasing antibiotic resistance (2010, background): “infections remains a challenge. The effectiveness of most commonly recommended treatments has declined to unacceptably low levels, largely related to development of resistance to clarithromycin.”
Prevalence of Antibiotic Resistance in Helicobacter pylori: A Systematic Review and Meta-analysis in World Health Organization Regions (2018, background): “The highest primary resistance rate registered for metronidazole and levofloxacin in the Western areas of the world likely relates to the massive use of metronidazole to treat parasite infestations in developing countries and to the increased consumption of fluoroquinolones in these regions.(13,27) ”
Review article: the global emergence of Helicobacter pylori antibiotic resistance (2015, background): “6%).(79) These mutations prevent the macrolide from binding.”