The biology and function of fibroblasts in cancer

By Raghu Kalluri. Nature Reviews. Cancer, 2016

3,789 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f245f1ef4065a5045a91370de62f1f4892ea2db7

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In Biotechnology

1. E. Henke
2. S. Ergün
3. R. Nandigama
4. E. Song
5. Muyue Yang
6. Xianqun Fan
7. Jipeng Li
8. P. Gu

In Molecular Biology

1. E. Song
2. E. Henke
3. S. Ergün
4. R. Nandigama
5. Muyue Yang
6. Xianqun Fan
7. Jipeng Li
8. P. Gu

In Oncology

1. E. Song
2. E. Henke
3. S. Ergün
4. R. Nandigama
5. Xianqun Fan
6. Muyue Yang
7. Jipeng Li
8. P. Gu

Citations in the corpus

• Cholangiocarcinoma 2020: the next horizon in mechanisms and management (2020, neutral): “CAFs are a heterogeneous population of spindle-shaped cells with mesenchymal origin that contribute to tumour progression in many human cancers 199 .”
• Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “apoptosis and improving the proliferation, migration and viability of cancer cells [58, 59].”
• Overcoming Endocrine Resistance in Breast Cancer (2020, neutral): “, 2014), and 3) microenvironmental components that affect drug sensitivity (Hirata et al., 2015; Kalluri, 2016; Ruffell and Coussens, 2015; Sahai et al., 2020).”
• Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy (2020, background): “All this is in stark contrast to the quiescent, metabolically inactive fibroblasts found in normal connective tissue (for a review on CAFs, see Kalluri, 2016).”
• Tumor Microenvironment Characterization in Gastric Cancer Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures (2019, background): “For example, differences in the compositions of resident cell types within the TME, including cytotoxic T cells, helper T cells, dendritic cells (DCs), tumor-associated macrophages, mesenchymal stem cells, and associated inflammatory pathways, have been reported in patients with cancer (5, 6, 9, 10)”
• Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. (2020, background): “org clusters (1, 2, 5) belong to the inflammatory (“iCAF”) subgroup and five CAF-S1 clusters (0, 3, 4, 6, 7) to the myofibroblastic (“myCAF”) subgroup, iCAF and myCAF having been previously identified in pancreatic cancer (7, 16, 26).”
• Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “It is widely accepted that fibroblasts in normal tissues are generally embedded within fibrillar ECM as single resting mesenchymal cells.(17) They are also defined by their cell morphology, tissue location, and lack of the lineage markers that are expressed by other cells, such as epithelial cells a”
• In search of definitions: Cancer‐associated fibroblasts and their markers (2019, background): “In addition, epigenetic changes could directly influence CAFs and their marker expression.(6) Future studies that systematically address the expression of CAF markers, combined with genomic and transcriptomic profile analysis of single fibroblasts, could potentially help elucidate these controversie”