Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition.
By S. Jackson, Alan R. Fersht. 1991
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Citations in the corpus
- The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. (2007, background): “However, a large body of work carried out over the past 15 years suggests that rugged folding free energy landscapes are quite rare in small, naturally occurring proteins; these proteins generally have highly cooperative folding transitions in which nonnative states are not significantly populated (”
- An All-atom Structure-Based Potential for Proteins: Bridging Minimal Models with All-atom Empirical Forcefields (2009, background): “2) have been experimentally47–49 and computationally8,50–52 well characterized.”
- Is there a unifying mechanism for protein folding? (2003, background): “A new mechanism for folding: nucleation-condensation The three classical mechanisms were thrown back into the ‘melting pot’ in the early 1990s by two events: (1) the discovery that proteins could fold by simple two-state kinetics, without the accumulation of folding intermediates [the archetype bein”
- Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome (2006, unknown): “Although in vivo rates of translation can vary considerably [64,65], they can average around 20 residues per second [93], which is similar to the experimentally measured refolding rates of both CI2 and barnase in water (50s 1 [39] and 13s 1 [42], respectively).”
- Topological and energetic factors: what determines the structural details of the transition state ensemble and "en-route" intermediates for protein folding? An investigation for small globular proteins. (2000, background): “…of the transition state for this protein has been extensively characterized by protein engineering (Itzhaki et al. 1995, Otzen & Fersht 1995, Jackson & Fersht 1991b), by free energy functional approaches (Shoemaker & Wolynes 1999, Shoemaker, Wang & Wolynes 1999), by a geometrical…”