Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.

By W. Lewis, L. Green, F. Grynszpan, Z. Radić, P. Carlier, Palmer Taylor, M. Finn, K. Sharpless. Angewandte Chemie, 2002

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Fragment-based lead discovery (2004, background): “The building blocks are substantially larger and higher affinity than many of the fragments described above, but the example is included to illustrate the concept of self-assembl”
Recent advance in the support and technology used in enzyme immobilization (2009, background): “Click-chemistry protocol has attracted great attention in the past several years, and it has been applied in organic synthesis, medicinal chemistry, polymer and material sciences, bioconjugate and peptide chemistry (Lewis et al., 2002).”