Crypt stem cells as the cells-of-origin of intestinal cancer

By Nick Barker, Rachel A. Ridgway, J. V. Es, M. Wetering, H. Begthel, M. V. D. Born, E. Danenberg, A. Clarke, O. Sansom, Hans Clevers. Nature, 2009

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Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. (2013, background): “Our results agree with previous findings and show that neither in vitro nor in vivo single stabilization of b-catenin nor loss of Apc alone is sufficient to drive dedifferentiation (Barker et al., 2009).”
Targeting MET in cancer: rationale and progress (2012, background): “These findings are important because, although the role of WNT–β-catenin signalling in cancer stem cells is well known, that of HGF/SF–MET has only just emerge”
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, background): “Mouse Lgr5 + cells give rise to intestinal tumors with higher efficiency than other intestinal epithelial cell populations upon mutational activation of the Wnt pathway (Barker et al., 2008).”