Neurotoxins affecting neuroexocytosis.

By G. Schiavo, M. Matteoli, C. Montecucco. Physiological Reviews, 2000

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Gβγ acts at the C terminus of SNAP-25 to mediate presynaptic inhibition (2005, background): “Known to be among the most selective proteases, botulinum toxins are widely used to manipulate SNARE proteins in intact neuron”
Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling (2010, background): “Botulinum neurotoxin B (BoTox) and tetanus toxin (TeTox) block exocytosis by proteolytic cleavage of synaptobrevin/VAMP2, which is critical for exocytosis (Schiavo et al, 2000).”
Multiple roles of calcium ions in the regulation of neurotransmitter release. (2008, background): “Another group of ‘‘modulators’’ are the clostridial neurotoxins, which have long been known to target the core of the release machinery—the SNARE proteins (Blasi et al., 1993; Chen and Scheller, 2001; Schiavo et al., 2000).”
Proteases as therapeutics (2011, neutral): “378, 705–716 13 Scott, C. J. and Taggart, C. C. (2010) Biologic protease inhibitors as novel therapeutic agents.”