Immune regulatory function of B cells.

By C. Mauri, A. Bosma. Annual Review of Immunology, 2012

1,257 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/f0ff391e7c5e342e50f60293bb19c13a357486c1

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In Immunology

1. E. Rosser
2. C. Mauri
3. T. Hagemann
4. M. Capasso
5. F. Balkwill
6. J. Joyce
7. Lisa M. Coussens
8. D. Hanahan

Citations in the corpus

• Regulatory B cells: origin, phenotype, and function. (2015, background): “Over the past decade, a population of suppressor B cells, collectively known as regulatory B (Breg) cells, have been associated with the inhibition of excessive inflammation (Mauri and Bosma, 2012).”
• Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions (2023, background): “Regulatory B cells (Bregs) are a functional B cell subpopulation with the key function of secreting IL-10, thereby preventing the production of cytokines.(274) HIF-1α is a tumor suppressor in some cancers.”
• CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation (2013, background): “These regulatory B cells (Bregs) have been shown to suppress via the release of interleukin-10 (IL-10) or transforming growth factor–b (TGF-b) by engagement of costimulatory molecules (CD80/CD86), through antigen presentation, and by induction of regulatory T cell (Treg) populations (6).”
• The tumor microenvironment at a glance (2012, background): “An immunosuppressive population of IL-10producing B cells, known as regulatory B cells (Bregs) or B10 cells (Mauri and Bosma, 2012), increases tumor burden and inhibits tumor-specific immune responses in inflammation-induced skin cancer (Schioppa et al., 2011), and also appear to favor lung…”
• Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “Regulatory B (Breg) cells are a subpopulation of B cells characterized by their unique immunoregulatory and immunosuppressive qualities, possessing an important role in peripheral tolerance.(92) Accordingly, Breg cells have been associated with worse clinical outcome in cancer.”