RADIATION DOSE–VOLUME EFFECTS IN RADIATION-INDUCED RECTAL INJURY

By J. Michalski, H. Gay, A. Jackson, S. Tucker, J. Deasy. International Journal of Radiation Oncology, Biology, Physics, 2010

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The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04–0.14); m = 0.13 (0.10–0.17); and TD50 = 76.9 (73.7–80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions.

Subfields: Radiation, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/f0ed269ad6274ad462f4c2a1d984d7a3e3bc3437