Dietary supplementation of bile acid attenuate adverse effects of high-fat diet on growth performance, antioxidant ability, lipid accumulation and intestinal health in juvenile largemouth bass…

By Peng Yin, Shi‐wei Xie, Zhenxiao Zhuang, Xuanshu He, Xi-Kang Tang, L. Tian, Yong‐jian Liu, J. Niu. 2021

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Abstract Bile acid (BA) has been reported to improve growth performance and play an important role in lipid metabolism of fish. Five diets were formulated to investigate the effects of dietary bile acid (chenodeoxycholic acid) supplementation on growth performance, antioxidant capacity, lipid metabolism and intestinal health of juvenile largemouth bass (Micropterus salmoides). Fish (18.35 ± 0.05 g) were randomly fed five diets: the positive control diet (10.87% lipid, C), high fat diet (18.08% lipid, HF), and HF diets supplemented with 300, 600 and 900 mg/kg chenodeoxycholic acid (HFC1, HFC2 and HFC3, respectively). After 9 weeks of feeding experiment, the weight gain (WG) and special growth rate (SGR) were significantly lower in the fish fed diet HF compared with those fed diet C (P   0.05). Viscerosomatic index (VSI) and intraperitoneal fat ratio (IPF) were significantly higher in fish fed high fat diets than those fed the control diet (P   0.05). With increasing supplementation of BA in diets, the crude lipid of muscle gradually decreased. Triglyceride (TG), malondialdehyde (MDA) in plasma and MDA in liver were higher in HF group than control group, addition of BA could decrease those contents effectively and increase the gene expression of SOD and GSH-Px. Lipidprotein transport and cholesterol synthesis related mRNA levels were significantly increased in fish fed high fat diets containing BA. The supplementation of 900 mg/kg BA significantly increased the gene expression of apolipoprotein B (ApoB-100), sterol 26-hydroxylase (CYP27α) and liver X receptor (LXR) (P

Subfields: Aquatic Science, Molecular Biology, Oncology

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