Synaptic representation of locomotion in single cerebellar granule cells
By K. Powell, Alexandre Mathy, Ian Duguid, Michael Häusser. 2015
110 citations recorded by the source corpus.
The cerebellum plays a crucial role in the regulation of locomotion, but how movement is represented at the synaptic level is not known. Here, we use in vivo patch-clamp recordings to show that locomotion can be directly read out from mossy fiber synaptic input and spike output in single granule cells. The increase in granule cell spiking during locomotion is enhanced by glutamate spillover currents recruited during movement. Surprisingly, the entire step sequence can be predicted from input EPSCs and output spikes of a single granule cell, suggesting that a robust gait code is present already at the cerebellar input layer and transmitted via the granule cell pathway to downstream Purkinje cells. Thus, synaptic input delivers remarkably rich information to single neurons during locomotion. DOI: http://dx.doi.org/10.7554/eLife.07290.001
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
In Neurology
Citations in the corpus
- Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Mossy fibres carry sensory and motor information (van Kan et al., 1993; Arenz et al., 2008; Huang et al., 2013; Proville et al., 2014; Powell et al., 2015) to the cerebellar input layer (or granule cell layer’), where they form multiple ‘en passant’ presynaptic boutons.”
- Multimodal sensory integration in single cerebellar granule cells in vivo (2015, background): “Integration of sensory and motor inputs should to be tested in future studies using recordings from granule cells in awake behaving animals (Powell et al., 2015).”