The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry.

By Thomas R. Insel. American Journal of Psychiatry, 2014

1,371 citations recorded by the source corpus.

Subfields: Psychiatry and Mental health, Philosophy

View Paper: https://www.semanticscholar.org/paper/f087cfb3a35a9d9f2a23658ff489dfbf5cb7f6f0

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Citations in the corpus

Revealing Neurocomputational Mechanisms of Reinforcement Learning and Decision-Making With the hBayesDM Package (2016, methodology): “…or not two groups are the same on the parameter of interest), for which Bayesian hypothesis testing (e.g., the Bayes factor; Kass & Raftery, 1995; Myung & Pitt, 1997; Wagenmakers, 2007) or a region of practical equivalence (ROPE) around the null value should be used instead (Kruschke, 2011, 2014).”
Individual differences in stress susceptibility and stress inhibitory mechanisms (2017, positive): “Underlining the importance of research in this field, individual differences in response to threat and loss is listed in the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health (NIMH) as a strategy to guide research on mechanisms of psychopathology [6].”
Automated assessment of psychiatric disorders using speech: A systematic review (2019, background): “30 Therefore, algorithms trained on behavioral descriptors could provide likelihood estimates for different disorders to aid clinicians in differential diagnosis (eg, determining whether a patient meets criteria for unipolar depression or bipolar disorder 31 ), help detect risk for chronic…”
Inflammation and clinical response to treatment in depression: A meta-analysis. (2015, neutral): “Indeed, combining a range of inflammatory and other markers might be useful in enhancing treatment personalisation and diagnostic accuracy in the future, and complements current strategies to link clinical syndromes more closely to underlying neurobiological and other substrates (Insel, 2014).”
Transdiagnostic Approaches to Mental Health Problems: Current Status and Future Directions (2020, methodology): “…is a gathering apprehension that the taxonomic approach instantiated in the DSM and ICD runs counter to the available clinical and research evidence and may hamper our understanding of mental ill health and consequently how we manage and treat mental distress (Insel, 2014; Kotov et al., 2017).”
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders (2015, background): “It is hoped that genetics may enable more tailored psychotropic prescribing termed personalized medicine, and this concept is gaining momentum as the cost of genotyping has reduced (Insel, 2014).”
The WHO World Mental Health Surveys International College Student Project: Prevalence and Distribution of Mental Disorders (2018, positive): “In line with the precision medicine initiative approach (Insel, 2014), the next step in this work will be to begin constructing personalized approaches that both identify each student’s risk profile and then, provide access to intervention resources designed to ameliorate the negative effects of…”
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments (2023, background): “…to de ﬁ ne a target that is speci ﬁ c and amenable to modulation, and in which its modulation will impact behavior (e.g., by changing functional activity/connectivity in the brain target that may affect clinical/behavioral outcomes as the NIMH Research Domain Criteria (RDoC) suggests [10]).”